Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain.
Identifieur interne : 000124 ( Main/Exploration ); précédent : 000123; suivant : 000125Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain.
Auteurs : A. Ant N [Espagne] ; M A Marcos [Espagne] ; N. Torner [Espagne] ; R. Isanta [Espagne] ; M. Camps [Espagne] ; A. Martínez [Espagne] ; A. Domínguez [Espagne] ; M. Jané [Espagne] ; M T Jiménez De Anta [Espagne] ; T. Pumarola [Espagne]Source :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [ 1469-0691 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Culture virale (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (épidémiologie), Femelle (MeSH), Humains (MeSH), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Jeune adulte (MeSH), Maladies virales (virologie), Maladies virales (épidémiologie), Mâle (MeSH), Nourrisson (MeSH), Partie nasale du pharynx (virologie), Réaction de polymérisation en chaîne (MeSH), Sujet âgé (MeSH), Surveillance épidémiologique (MeSH), Technique d'immunofluorescence (MeSH), Virus (classification), Virus (isolement et purification), Épidémiologie moléculaire (MeSH), Évolution moléculaire (MeSH).
- MESH :
- isolement et purification : Virus.
- virologie : Infections de l'appareil respiratoire, Maladies virales, Partie nasale du pharynx.
- épidémiologie : Espagne, Infections de l'appareil respiratoire, Maladies virales.
- classification : Adolescent, Adulte, Adulte d'âge moyen, Culture virale, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Réaction de polymérisation en chaîne, Sujet âgé, Surveillance épidémiologique, Technique d'immunofluorescence, Virus, Épidémiologie moléculaire, Évolution moléculaire.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Child (MeSH), Child, Preschool (MeSH), Epidemiological Monitoring (MeSH), Evolution, Molecular (MeSH), Female (MeSH), Fluorescent Antibody Technique (MeSH), Humans (MeSH), Infant (MeSH), Male (MeSH), Middle Aged (MeSH), Molecular Epidemiology (MeSH), Nasopharynx (virology), Polymerase Chain Reaction (MeSH), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (virology), Spain (epidemiology), Virus Cultivation (MeSH), Virus Diseases (epidemiology), Virus Diseases (virology), Viruses (classification), Viruses (isolation & purification), Young Adult (MeSH).
- MESH :
- classification : Viruses.
- epidemiology : Respiratory Tract Infections, Spain, Virus Diseases.
- isolation & purification : Viruses.
- virology : Nasopharynx, Respiratory Tract Infections, Virus Diseases.
- Adolescent, Adult, Aged, Child, Child, Preschool, Epidemiological Monitoring, Evolution, Molecular, Female, Fluorescent Antibody Technique, Humans, Infant, Male, Middle Aged, Molecular Epidemiology, Polymerase Chain Reaction, Virus Cultivation, Young Adult.
Abstract
Most attention is given to seasonal influenza and respiratory syncytial virus outbreaks, but the cumulative burden caused by other respiratory viruses (RV) is not widely considered. The aim of the present study is to describe the circulation of RV in the general population during six consecutive seasons from 2006 to 2012 in Catalonia, Spain. Cell culture, immunofluorescence and PCR-based assays were used for the RV laboratory-confirmation and influenza subtyping. Phylogenetic and molecular characterizations of viral haemagglutinin, partial neuraminidase and matrix 2 proteins were performed from a representative sampling of influenza viruses. A total of 6315 nasopharyngeal samples were collected, of which 64% were laboratory-confirmed, mainly as influenza A viruses and rhinoviruses. Results show the significant burden of viral aetiological agents in acute respiratory infection, particularly in the youngest cases. The study of influenza strains reveals their continuous evolution through either progressive mutations or by segment reassortments. Moreover, the predominant influenza B lineage was different from that included in the recommended vaccine in half of the studied seasons, supporting the formulation and use of a quadrivalent influenza vaccine. Regarding neuraminidase inhibitors resistance, with the exception of the 2007/08 H275Y seasonal A(H1N1) strains, no other circulating influenza strains carrying known resistance genetic markers were found. Moreover, all circulating A(H1N1)pdm09 and A(H3N2) strains finally became genetically resistant to adamantanes. A wide knowledge of the seasonality patterns of the RV in the general population is well-appreciated, but it is a challenge due to the unpredictable circulation of RV, highlighting the value of local and global RV surveillance.
DOI: 10.1016/j.cmi.2016.02.007
PubMed: 26939538
PubMed Central: PMC7172104
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: aanton76@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Marcos, M A" sort="Marcos, M A" uniqKey="Marcos M" first="M A" last="Marcos">M A Marcos</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Torner, N" sort="Torner, N" uniqKey="Torner N" first="N" last="Torner">N. Torner</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Isanta, R" sort="Isanta, R" uniqKey="Isanta R" first="R" last="Isanta">R. 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Martínez</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Dominguez, A" sort="Dominguez, A" uniqKey="Dominguez A" first="A" last="Domínguez">A. 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Jané</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Agency of Catalonia, Government of Catalonia, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Jimenez De Anta, M T" sort="Jimenez De Anta, M T" uniqKey="Jimenez De Anta M" first="M T" last="Jiménez De Anta">M T Jiménez De Anta</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pumarola, T" sort="Pumarola, T" uniqKey="Pumarola T" first="T" last="Pumarola">T. Pumarola</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26939538</idno><idno type="pmid">26939538</idno><idno type="doi">10.1016/j.cmi.2016.02.007</idno><idno type="pmc">PMC7172104</idno><idno type="wicri:Area/Main/Corpus">00145</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00145</idno><idno type="wicri:Area/Main/Curation">000145</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000145</idno><idno type="wicri:Area/Main/Exploration">000145</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain.</title><author><name sortKey="Ant N, A" sort="Ant N, A" uniqKey="Ant N A" first="A" last="Ant N">A. Ant N</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain. Electronic address: aanton76@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Marcos, M A" sort="Marcos, M A" uniqKey="Marcos M" first="M A" last="Marcos">M A Marcos</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Torner, N" sort="Torner, N" uniqKey="Torner N" first="N" last="Torner">N. Torner</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Isanta, R" sort="Isanta, R" uniqKey="Isanta R" first="R" last="Isanta">R. Isanta</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Camps, M" sort="Camps, M" uniqKey="Camps M" first="M" last="Camps">M. Camps</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martinez, A" sort="Martinez, A" uniqKey="Martinez A" first="A" last="Martínez">A. Martínez</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Dominguez, A" sort="Dominguez, A" uniqKey="Dominguez A" first="A" last="Domínguez">A. Domínguez</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Jane, M" sort="Jane, M" uniqKey="Jane M" first="M" last="Jané">M. Jané</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Agency of Catalonia, Government of Catalonia, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Jimenez De Anta, M T" sort="Jimenez De Anta, M T" uniqKey="Jimenez De Anta M" first="M T" last="Jiménez De Anta">M T Jiménez De Anta</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pumarola, T" sort="Pumarola, T" uniqKey="Pumarola T" first="T" last="Pumarola">T. Pumarola</name><affiliation wicri:level="3"><nlm:affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</title><idno type="eISSN">1469-0691</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Epidemiological Monitoring (MeSH)</term><term>Evolution, Molecular (MeSH)</term><term>Female (MeSH)</term><term>Fluorescent Antibody Technique (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Molecular Epidemiology (MeSH)</term><term>Nasopharynx (virology)</term><term>Polymerase Chain Reaction (MeSH)</term><term>Respiratory Tract Infections (epidemiology)</term><term>Respiratory Tract Infections (virology)</term><term>Spain (epidemiology)</term><term>Virus Cultivation (MeSH)</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (virology)</term><term>Viruses (classification)</term><term>Viruses (isolation & purification)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Culture virale (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections de l'appareil respiratoire (épidémiologie)</term><term>Jeune adulte (MeSH)</term><term>Maladies virales (virologie)</term><term>Maladies virales (épidémiologie)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Partie nasale du pharynx (virologie)</term><term>Réaction de polymérisation en chaîne (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Surveillance épidémiologique (MeSH)</term><term>Technique d'immunofluorescence (MeSH)</term><term>Virus (classification)</term><term>Virus (isolement et purification)</term><term>Épidémiologie moléculaire (MeSH)</term><term>Évolution moléculaire (MeSH)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Respiratory Tract Infections</term><term>Spain</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term><term>Partie nasale du pharynx</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasopharynx</term><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Epidemiological Monitoring</term><term>Evolution, Molecular</term><term>Female</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Molecular Epidemiology</term><term>Polymerase Chain Reaction</term><term>Virus Cultivation</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Culture virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Réaction de polymérisation en chaîne</term><term>Sujet âgé</term><term>Surveillance épidémiologique</term><term>Technique d'immunofluorescence</term><term>Virus</term><term>Épidémiologie moléculaire</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most attention is given to seasonal influenza and respiratory syncytial virus outbreaks, but the cumulative burden caused by other respiratory viruses (RV) is not widely considered. The aim of the present study is to describe the circulation of RV in the general population during six consecutive seasons from 2006 to 2012 in Catalonia, Spain. Cell culture, immunofluorescence and PCR-based assays were used for the RV laboratory-confirmation and influenza subtyping. Phylogenetic and molecular characterizations of viral haemagglutinin, partial neuraminidase and matrix 2 proteins were performed from a representative sampling of influenza viruses. A total of 6315 nasopharyngeal samples were collected, of which 64% were laboratory-confirmed, mainly as influenza A viruses and rhinoviruses. Results show the significant burden of viral aetiological agents in acute respiratory infection, particularly in the youngest cases. The study of influenza strains reveals their continuous evolution through either progressive mutations or by segment reassortments. Moreover, the predominant influenza B lineage was different from that included in the recommended vaccine in half of the studied seasons, supporting the formulation and use of a quadrivalent influenza vaccine. Regarding neuraminidase inhibitors resistance, with the exception of the 2007/08 H275Y seasonal A(H1N1) strains, no other circulating influenza strains carrying known resistance genetic markers were found. Moreover, all circulating A(H1N1)pdm09 and A(H3N2) strains finally became genetically resistant to adamantanes. A wide knowledge of the seasonality patterns of the RV in the general population is well-appreciated, but it is a challenge due to the unpredictable circulation of RV, highlighting the value of local and global RV surveillance. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26939538</PMID><DateCompleted><Year>2017</Year><Month>01</Month><Day>26</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-0691</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</Title><ISOAbbreviation>Clin. Microbiol. Infect.</ISOAbbreviation></Journal><ArticleTitle>Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain.</ArticleTitle><Pagination><MedlinePgn>564.e1-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmi.2016.02.007</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1198-743X(16)00115-4</ELocationID><Abstract><AbstractText>Most attention is given to seasonal influenza and respiratory syncytial virus outbreaks, but the cumulative burden caused by other respiratory viruses (RV) is not widely considered. The aim of the present study is to describe the circulation of RV in the general population during six consecutive seasons from 2006 to 2012 in Catalonia, Spain. Cell culture, immunofluorescence and PCR-based assays were used for the RV laboratory-confirmation and influenza subtyping. Phylogenetic and molecular characterizations of viral haemagglutinin, partial neuraminidase and matrix 2 proteins were performed from a representative sampling of influenza viruses. A total of 6315 nasopharyngeal samples were collected, of which 64% were laboratory-confirmed, mainly as influenza A viruses and rhinoviruses. Results show the significant burden of viral aetiological agents in acute respiratory infection, particularly in the youngest cases. The study of influenza strains reveals their continuous evolution through either progressive mutations or by segment reassortments. Moreover, the predominant influenza B lineage was different from that included in the recommended vaccine in half of the studied seasons, supporting the formulation and use of a quadrivalent influenza vaccine. Regarding neuraminidase inhibitors resistance, with the exception of the 2007/08 H275Y seasonal A(H1N1) strains, no other circulating influenza strains carrying known resistance genetic markers were found. Moreover, all circulating A(H1N1)pdm09 and A(H3N2) strains finally became genetically resistant to adamantanes. A wide knowledge of the seasonality patterns of the RV in the general population is well-appreciated, but it is a challenge due to the unpredictable circulation of RV, highlighting the value of local and global RV surveillance. </AbstractText><CopyrightInformation>Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Antón</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain. Electronic address: aanton76@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcos</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torner</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isanta</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camps</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domínguez</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain; Public Health Department, Faculty of Medicine, University of Barcelona, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jané</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Public Health Agency of Catalonia, Government of Catalonia, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiménez de Anta</LastName><ForeName>M T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pumarola</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>WHO National Influenza Centre, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clinic Barcelona - ISGlobal - University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Clin Microbiol Infect</MedlineTA><NlmUniqueID>9516420</NlmUniqueID><ISSNLinking>1198-743X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D062665" MajorTopicYN="N">Epidemiological Monitoring</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005455" MajorTopicYN="N">Fluorescent Antibody Technique</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017720" MajorTopicYN="N">Molecular Epidemiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014776" MajorTopicYN="N">Virus Cultivation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Influenza viruses</Keyword><Keyword MajorTopicYN="N">molecular epidemiology</Keyword><Keyword MajorTopicYN="N">respiratory syncytial virus</Keyword><Keyword MajorTopicYN="N">respiratory viruses</Keyword><Keyword MajorTopicYN="N">surveillance</Keyword><Keyword MajorTopicYN="N">type/subtype/lineage</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>01</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>11</Day></PubMedPubDate><PubMedPubDate 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IdType="pubmed">19300497</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Ant N, A" sort="Ant N, A" uniqKey="Ant N A" first="A" last="Ant N">A. Ant N</name></region><name sortKey="Camps, M" sort="Camps, M" uniqKey="Camps M" first="M" last="Camps">M. Camps</name><name sortKey="Dominguez, A" sort="Dominguez, A" uniqKey="Dominguez A" first="A" last="Domínguez">A. Domínguez</name><name sortKey="Isanta, R" sort="Isanta, R" uniqKey="Isanta R" first="R" last="Isanta">R. Isanta</name><name sortKey="Jane, M" sort="Jane, M" uniqKey="Jane M" first="M" last="Jané">M. Jané</name><name sortKey="Jimenez De Anta, M T" sort="Jimenez De Anta, M T" uniqKey="Jimenez De Anta M" first="M T" last="Jiménez De Anta">M T Jiménez De Anta</name><name sortKey="Marcos, M A" sort="Marcos, M A" uniqKey="Marcos M" first="M A" last="Marcos">M A Marcos</name><name sortKey="Martinez, A" sort="Martinez, A" uniqKey="Martinez A" first="A" last="Martínez">A. Martínez</name><name sortKey="Pumarola, T" sort="Pumarola, T" uniqKey="Pumarola T" first="T" last="Pumarola">T. Pumarola</name><name sortKey="Torner, N" sort="Torner, N" uniqKey="Torner N" first="N" last="Torner">N. Torner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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